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Nifedipine, 98%, Thermo Scientific Chemicals

Catalog No. AAJ6281106
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L-type calcium channel blocker; induces apoptosis in human glioblastoma cells

L-type calcium channel blocker; induces apoptosis in human glioblastoma cells.Nifedipine is a dihydropyridine calcium channel blocker used as L-type calcium channel blocker, antianginal and an antihypertensive . It induces apoptosis in human glioblastoma cells. It is used as a coronary vasodilator in the treatment of cardiac and circulatory disorders. Further, it is used in high-altitude medicine to treat high altitude pulmonary edema, hypertension and chronic stable angina. In addition, it is frequently used as a tocolytic agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
L-type calcium channel blocker; induces apoptosis in human glioblastoma cells.Nifedipine is a dihydropyridine calcium channel blocker used as L-type calcium channel blocker, antianginal and an antihypertensive . It induces apoptosis in human glioblastoma cells. It is used as a coronary vasodilator in the treatment of cardiac and circulatory disorders. Further, it is used in high-altitude medicine to treat high altitude pulmonary edema, hypertension and chronic stable angina. In addition, it is frequently used as a tocolytic agent.

Solubility
Soluble in acetone, methylene chloride, chloroform, ethyl acetate, dimethyl sulfoxide and methanol. Sparingly soluble in ethanol. Insoluble in water.

Notes
Light sensitive. Store in a cool place. Incompatible with strong acids, strong oxidizing agents, caustics, aliphatic amines, amides, diethylamine, potassium hydride and potassium hydroxide.

Chemical Identifiers

CAS

21829-25-4

Molecular Formula

C17H18N2O6

Molecular Weight (g/mol)

346.34

MDL Number

MFCD00057326

InChI Key

HYIMSNHJOBLJNT-UHFFFAOYSA-N

Synonym

nifedipine, procardia, adalat, procardia xl, adalat cc, cordipin, corinfar, fenihidine, citilat, oxcord

PubChem CID

4485

ChEBI

CHEBI:7565

IUPAC Name

3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

SMILES

COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1[N+]([O-])=O)C(=O)OC

Specifications

Melting Point

171°C to 175°C

Color

White to Yellow

Quantity

5 g

Merck Index

14,6528

Solubility Information

Soluble in acetone,methylene chloride,chloroform,ethyl acetate,dimethyl sulfoxide and methanol. Sparingly soluble in ethanol. Insoluble in water.

Formula Weight

346.33

Percent Purity

98%

Physical Form

Powder

Chemical Name or Material

Nifedipine

Hazard Category

H302

Hazard Statement

GHS H Statement
H302
Harmful if swallowed.

Precautionary Statement

P264b-P270-P301+P312-P330-P501c

EINECSNumber

244-598-3

RTECSNumber

US7975000

TSCA

No

Recommended Storage

Ambient temperatures
SDS

RUO – Research Use Only

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