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Nitrendipine, Thermo Scientific Chemicals

Catalog No. AAJ60841ME
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L-type calcium channel blocker

Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Chemical Identifiers

CAS

39562-70-4

Molecular Formula

C18H20N2O6

Molecular Weight (g/mol)

360.366

MDL Number

MFCD00082255

InChI Key

PVHUJELLJLJGLN-UHFFFAOYSA-N

Synonym

nitrendipine, bayotensin, baypress, nidrel, nitrendipinum, nitrendipino, bylotensin, nitrendipin, deiten, nitrepin

PubChem CID

4507

ChEBI

CHEBI:7582

IUPAC Name

5-O-ethyl 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

SMILES

CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C

Specifications

Color

Yellow to Green

Quantity

500 mg

Merck Index

14,6576

Solubility Information

Soluble in DMSO (17.5mg/ml),methanol (15mg/ml),ethyl acetate,and ethanol (25 mM). Insoluble in water.

Formula Weight

360.36

Physical Form

Powder

Chemical Name or Material

Nitrendipine

Hazard Category

H302+H312+H332

Hazard Statement

GHS H Statement
H302-H312-H332
Harmful if swallowed.
Harmful in contact with skin.
Harmful if inhaled.

Precautionary Statement

P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P312-P330-P363-P501c

EINECSNumber

254-513-1

RTECSNumber

US5653000

TSCA

No

Recommended Storage

Ambient temperatures

RUO – Research Use Only

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