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NS 3623, Tocris Bioscience™

Catalog No. 446250 Shop All R&D Systems Products
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KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic

KV11.1 (hERG) and KV4.3 channel activator. Activates the IKr and Ito currents and displays antiarrhythmic activity. May also act as a partial blocker of KV11.1 channels. Displays selectivity over the key cardiac potassium channels, KV7.1 (KCNQ1) and KV1.5. Suitable for both in vitro and in vivo use.

Chemical Identifiers

CAS

343630-41-1

Molecular Formula

C15H10BrF3N6O

Molecular Weight (g/mol)

427.185

InChI Key

JXPULDIATMTIIN-UHFFFAOYSA-N

PubChem CID

9954236

IUPAC Name

1-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea

SMILES

C1=CC(=CC(=C1)NC(=O)NC2=C(C=C(C=C2)Br)C3=NNN=N3)C(F)(F)F

Specifications

Quantity

50 mg

Synonym

d0jy2k, 1-4-bromo-2-2h-tetrazol-5-yl phenyl-3-3-trifluoromethyl phenyl urea, i kr agonists arrhythmia , neurosearch, herg potassium channel openers arrhythmia, herg potassium channel openers arrhythmia, n-4-bromo-2-1h-tetrazol-5-yl-phenyl-n'-3'-trifluoromethylphenyl urea, n-4-bromo-2-1h-tetrazol-5-yl-phenyl-n'-3-trifluoromethyl phenyl-urea, rapid delayed-rectifier current activators acquired long qt syndrome, 1-4-bromo-2-1h-1,2,3,4-tetrazol-5-yl phenyl-3-3-trifluoromethyl phenyl urea

Formula Weight

427.18

Percent Purity

>99%

Chemical Name or Material

NS 3623

Recommended Storage

Store at +4°C
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