NS 3623, Tocris Bioscience™

Description

KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic

KV11.1 (hERG) and KV4.3 channel activator. Activates the IKr and Ito currents and displays antiarrhythmic activity. May also act as a partial blocker of KV11.1 channels. Displays selectivity over the key cardiac potassium channels, KV7.1 (KCNQ1) and KV1.5. Suitable for both in vitro and in vivo use.

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Specifications

Chemical Identifiers

• CAS: 343630-41-1
• Molecular Formula: C15H10BrF3N6O
• Molecular Weight (g/mol): 427.185
• InChI Key: JXPULDIATMTIIN-UHFFFAOYSA-N
• PubChem CID: 9954236
• IUPAC Name: 1-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea
• SMILES: C1=CC(=CC(=C1)NC(=O)NC2=C(C=C(C=C2)Br)C3=NNN=N3)C(F)(F)F

• Quantity: 10 mg
• Synonym: d0jy2k, 1-4-bromo-2-2h-tetrazol-5-yl phenyl-3-3-trifluoromethyl phenyl urea, i kr agonists arrhythmia , neurosearch, herg potassium channel openers arrhythmia, herg potassium channel openers arrhythmia, n-4-bromo-2-1h-tetrazol-5-yl-phenyl-n'-3'-trifluoromethylphenyl urea, n-4-bromo-2-1h-tetrazol-5-yl-phenyl-n'-3-trifluoromethyl phenyl-urea, rapid delayed-rectifier current activators acquired long qt syndrome, 1-4-bromo-2-1h-1,2,3,4-tetrazol-5-yl phenyl-3-3-trifluoromethyl phenyl urea
• Formula Weight: 427.18
• Percent Purity: >99%
• Chemical Name or Material: NS 3623

Safety and Handling

Recommended Storage

Store at +4°C