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NU 7026, Tocris Bioscience™

Catalog No. p-4784221 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective DNA-PK inhibitor

ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.

Chemical Identifiers

CAS 154447-35-5
Molecular Formula C17H15NO3
Molecular Weight (g/mol) 281.311
InChI Key KKTZALUTXUZPSN-UHFFFAOYSA-N
Synonym dna-pk inhibitor ii, 2-morpholin-4-yl-benzo h chromen-4-one, 2-morpholino-4h-benzo h chromen-4-one, 2-4-morpholinyl-4h-naphtho 1,2-b pyran-4-one, 2-4-morpholinyl-4h-naphthol 1,2-b pyran-4-one, 2-morpholin-4-ylbenzo h chromen-4-one, dna-dependent protein kinase inhibitor ii, 2-morpholin-4-yl benzo h chromen-4-one, d03tvf, d0w1st
PubChem CID 9860529
IUPAC Name 2-morpholin-4-ylbenzo[h]chromen-4-one
SMILES C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3

Specifications

Quantity 10 mg
Formula Weight 281.31
Percent Purity >98%
Chemical Name or Material NU 7026

Safety and Handling

Recommended Storage Store at +4°C
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