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Nutlin 3a

Catalog No. 60755 Shop All R&D Systems Products
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MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

Nutlin 3a is an MDM2 antagonist (IC50 = 90 nM); inhibits the MDM2-p53 interaction. Active enantiomer of Nutlin-3 (Cat. No. 3984). Induces expression for P53 regulated genes. Suppresses tumor growth in vivo >98% in prostate cancer and osteosarcoma cancer models. Antiproliferative.

Specifications

Chemical Name or Material

4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

CAS

675576-98-4

Assay Percent Range

>97%

Quantity

5 mg

Molecular Formula

C30H30Cl2N4O4

Formula Weight

Observed MW: 581.49

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