Thermo Scientific Chemicals Paclitaxel, 99+%

Paclitaxel, also known as Taxol, CAS # 33069-62-4 is a chemotherapeutic drug that acts through stabilizing microtubule assembly and arresting cell cycle progression.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Paclitaxel is a naturally ocurring compound originally isolated from the tree T. brevifolia

Paclitaxel binds tubulin and stabilizes microtubule formation, preventing disassembly

Paclitaxel is used as a drug to arrest cells at the mitotic checkpoint and block cell cycle progression, thus inducing death of cancer cells

Applications

Paclitaxel can be used in preclinical laboratory research on diseases such as cancer, heart disease, inflammatory disorders, and hepatic fibrosis

Paclitaxel can be used as a tool in cell biology to study mitotic checkpoint arrest conditions and downstream signaling cascades

Chemical Identifiers

CAS

33069-62-4

Molecular Formula

C47H51NO14

Molecular Weight (g/mol)

853.92

MDL Number

MFCD00869953

InChI Key

RCINICONZNJXQF-VAZQATRQSA-N

Synonym

paclitaxel, taxol, taxol a, abraxane, paxene, paxceed, plaxicel, yewtaxan, onxol, ebetaxel

PubChem CID

133640187

IUPAC Name

(1S,2S,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate

SMILES

CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C1=CC=CC=C1)C1=CC=CC=C1

Melting Point

213.0°C to 216.0°C

Color

White

Infrared Spectrum

Authentic

Assay Percent Range

99% min. (HPLC)

Quantity

25 mg

Merck Index

15, 7081

Solubility Information

Solubility in water: sparingly soluble. Other solubilities: soluble in methanol,dmso,acetonitrile

Formula Weight

853.9

Percent Purity

99+%

Physical Form

Powder

Chemical Name or Material

Paclitaxel, 99+%

Hazard Category

GHS Signal Word: Danger

Hazard Statement

GHS H Statement:
Causes serious eye damage.
Suspected of causing cancer.

Precautionary Statement

GHS P Statement:
Wear eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/physician.
Use personal protective equipment as required.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

RTECSNumber

DA8340700

SDS

Hazard Category

GHS Signal Word: Danger

Hazard Statement

GHS H Statement:
Causes serious eye damage.
Suspected of causing cancer.

Precautionary Statement

GHS P Statement:
Wear eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/physician.
Use personal protective equipment as required.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

RTECSNumber

DA8340700

SDS

RUO – Research Use Only