Paclitaxel, 99.5+%, Thermo Scientific Chemicals

Paclitaxel (CAS # 33069-62-4) is a microtubule inhibitor produced from the extract of the Pacific yew tree.

Promotes assembly and inhibits disassembly of microtubules (anti-cancer agent)Paclitaxel is widely used in chemotherapeutic compound. It is used to treat certain types of cancer such as ovarian cancer, breast cancer, lung cancer and pancreatic cancer among others. It interferes with the growth of cancer cells and slows down their growth and spread in the body. It is also used to treat AIDS-related Kaposi's sarcoma.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Paclitaxel is a tetracyclic diterpenoid isolated from the Pacific yew, Taxus brevifolia
• Paclitaxel acts as an antineoplastic agent by binding tubulin and preventing cell division
• Paclitaxel may also bind Bcl-2 and lead to disinhibition of apoptosis

Application

• Paclitaxel is used in the study of lung, breast, and ovarian cancers; it may be useful in the research of other cancer types
• It is suitable for cell culture, biochemistry, and molecular biology applications

Chemical Identifiers

CAS

33069-62-4

Molecular Formula

C47H51NO14

Molecular Weight (g/mol)

853.92

MDL Number

MFCD00869953

InChI Key

RCINICONZNJXQF-VAZQATRQSA-N

Synonym

paclitaxel, taxol, taxol a, abraxane, paxene, paxceed, plaxicel, yewtaxan, onxol, ebetaxel

PubChem CID

133640187

IUPAC Name

(1S,2S,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate

SMILES

CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C1=CC=CC=C1)C1=CC=CC=C1

Melting Point

213°C (decomposition)

Color

White

Quantity

500 mg

Beilstein

1420457

Merck Index

14,6982

Solubility Information

Soluble in DMSO (200mg/ml) or ethanol (40mg/ml); Soluble in dimethylsulfoxide,methanol,ethanol,acetonitrile,cremophor and dimehtylsulfamide; Sparingly soluble in aqueous buffer.

Formula Weight

853.91

Percent Purity

≥99.5%

Physical Form

Crystalline Solid

Chemical Name or Material

Paclitaxel

Hazard Category

H302+H312+H332-H318-H334-H335-H361

Hazard Statement

GHS H Statement
H334-H341-H361-H318-H302-H312-H332-H335-H315-H317
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Suspected of causing genetic defects.
Suspected of damaging fertility or the unborn child.
Causes serious eye damage.
Harmful if swallowed.
Harmful in contact with skin.
Harmful if inhaled.
May cause respiratory irritation.
Causes skin irritation.
May cause an allergic skin reaction.

Precautionary Statement

P201-P202-P261-P264b-P270-P271-P281-P285-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P312-P330-P342+P311-P363-P501c

RTECSNumber

DA8340700

TSCA

No

Recommended Storage

Store at -20°C

SDS

Hazard Category

H302+H312+H332-H318-H334-H335-H361

Hazard Statement

GHS H Statement
H334-H341-H361-H318-H302-H312-H332-H335-H315-H317
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Suspected of causing genetic defects.
Suspected of damaging fertility or the unborn child.
Causes serious eye damage.
Harmful if swallowed.
Harmful in contact with skin.
Harmful if inhaled.
May cause respiratory irritation.
Causes skin irritation.
May cause an allergic skin reaction.

Precautionary Statement

P201-P202-P261-P264b-P270-P271-P281-P285-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P312-P330-P342+P311-P363-P501c

RTECSNumber

DA8340700

TSCA

No

Recommended Storage

Store at -20°C

SDS

RUO – Research Use Only