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AdipoGen Paxilline
SDP

Supplier:  AdipoGen AGCN20167M005

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Chemical. CAS 57186-25-1. Formula C27H33NO4. MW 435.6. Isolated from Penicillium sp. Tremorgenic. Potent, selective and reversible inhibitor of high-conductance calcium-activated potassium BKCa channels. Reversible inhibitor of inositol 1,4,5-trisphosphate receptor InsP3. Sarco/endoplasmic reticulum Ca2 ATPase SERCA inhibitor. Liver X receptor LXRalpha and LXRbeta NR1H3 and NR1H2 agonist in biochemical and in vitro cell-based assays. Anticonvulsant. Apoptosis enhancer. Can sensitize various glioma cells to TRAIL-mediated apoptosis. Shown to protect neuronal cells against glutamate-induced cell death.

Catalog No. 50-256-2647


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