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PD 146176, Tocris Bioscience™

Catalog No. p-4784246 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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Description

Selective 15-lipoxygenase inhibitor

Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo.

Chemical Identifiers

CAS 4079-26-9
Molecular Formula C15H11NS
Molecular Weight (g/mol) 237.32
InChI Key ZGOOPZVQMLHPFM-UHFFFAOYSA-N
Synonym 6,11-dihydrothiochromeno 4,3-b indole, 6,11-dihydro 1 benzothiopyrano 4,3-b indole, 6,3-b indole, d0j8rs, 6,11-dihydro-5-thia-11-aza-benzo a fluorene, 1 benzothiopyrano 4, 6,11-dihydro, 6h,11h-thiochromeno 4,3-b indole, pd hplc , solid, 1 benzothiopyrano 4,3-b indole, 6,11-dihydro, 8-thia-17-azatetracyclo 8.7.0.0 2 ,?.0 1 1 , 1 ? heptadeca-1 10 ,2 7 ,3,5,11,13,15-heptaene
PubChem CID 297589
IUPAC Name 6,11-dihydrothiochromeno[4,3-b]indole
SMILES C1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24

Specifications

Quantity 10 mg
Formula Weight 237.32
Percent Purity >98%
Chemical Name or Material PD 146176

Safety and Handling

Recommended Storage Store at +4°C
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