Gibco™ PeproGMP® Human BMP-4 Recombinant Protein, PeproTech®

Recombinant Protein

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

Accession Number

P12644

For Use With (Application)

Functional Assay

Format

Lyophilized

Formulation

Protein with no preservative

Molecular Weight (g/mol)

24.2

Name

BMP4

Quantity

100 μg

Immunogen

Human BMP-4

Storage Requirements

-20°C or -80°C if preferred

Regulatory Status

RUO

Endotoxin Concentration

<0.1

Assays

Functional Assay

Conjugate

Unconjugated

Recombinant

Recombinant

Activity

Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.

Expression System

E. coli

Product Line

PeproGMP

Purity or Quality Grade

Purified