Gibco™ PeproGMP® Human Activin A Recombinant Protein, PeproTech®

Recombinant Protein

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.

Accession Number

P08476

For Use With (Application)

Functional Assay

Format

Lyophilized

Formulation

Protein with no preservative

Molecular Weight (g/mol)

26

Name

Activin A

Quantity

100 μg

Immunogen

Human Activin A

Storage Requirements

-20°C or -80°C if preferred

Regulatory Status

RUO

Endotoxin Concentration

<0.1

Assays

Functional Assay

Conjugate

Unconjugated

Recombinant

Recombinant

Activity

Determined by the proliferation of mouse MPC-11 cells. PeproGMP Recombinant Human Activin A has been tested against the WHO standard NIBSC 91/626.

Expression System

E. coli

Product Line

PeproGMP

Purity or Quality Grade

Purified