PF 431396, Tocris Bioscience™

Description

Dual FAK/PYK2 inhibitor

Dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.

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Specifications

Chemical Identifiers

• CAS: 717906-29-1
• Molecular Formula: C22H21F3N6O3S
• Molecular Weight (g/mol): 506.50
• MDL Number: MFCD16038300
• InChI Key: POJZIZBONPAWIV-UHFFFAOYSA-N
• Synonym: n-methyl-n-2-2-2-oxo-2,3-dihydro-1h-indol-5-yl amino-5-trifluoromethylpyrimidin-4-yl amino methyl phenyl methanesulfonamide, n-methyl-n-2-2-2-oxoindolin-5-yl amino-5-trifluoromethyl pyrimidin-4-yl amino methyl phenyl methanesulfonamide, n-methyl-n-2-2-2-oxoindolin-5-ylamino-5-trifluoromethyl pyrimidin-4-ylamino methyl phenyl methanesulfonamide, n-methyl-n-2-2-2-oxo-2,3-dihydro-1h-indol-5-yl amino-5-trifluoromethyl pyrimidin-4-yl amino methyl phenyl methanesulfonamide, 3fzr, n-methyl-n-2-2-2-oxo-1,3-dihydroindol-5-yl amino-5-trifluoromethyl pyrimidin-4-yl amino methyl phenyl methanesulfonamide, n-methyl-n-2-2-2,3-dihydro-2-oxo-1h-indol-5-yl amino-5-trifluoromethyl-4-pyrimidinyl amino methyl phenyl methanesulfonamide, n-2-2-2,3-dihydro-2-oxo-1h-indol-5-yl amino-5-trifluoromethyl-4-pyrimidinyl amino methyl phenyl-n-methyl-methanesulfonamide
• PubChem CID: 11598628
• IUPAC Name: N-methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide
• SMILES: CN(C1=CC=CC=C1CNC1=NC(NC2=CC3=C(NC(=O)C3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O

• Quantity: 10 mg
• Formula Weight: 506.5
• Percent Purity: >98%
• Chemical Name or Material: PF 431396

Safety and Handling

Recommended Storage

Store at +4°C