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PG 01037 dihydrochloride, Tocris Bioscience™

Catalog No. p-4816970 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

D3 receptor selective antagonist

Dopamine D3 receptor antagonist; 133-fold selective for D3 over D2 receptors in vitro (Ki values are 0.70, 93.3 and 375 nM for D3, D2 and D4 receptors respectively). Attenuates abnormal involuntary movements associated with L-DOPA (Cat. No. 3788) in rat models of Parkinson's disease. Inhibits the effects of methamphetamine; attenuates drug-induced behaviors in vivo.

Chemical Identifiers

CAS 675599-62-9
Molecular Formula C26H28Cl4N4O
Molecular Weight (g/mol) 554.337
InChI Key DACFFMAXBWGOKQ-CZEFNJPISA-N
Synonym pg 01037 dihydrochloride, n-2e-4-4-2,3-dichlorophenyl-1-piperazinyl-2-buten-1-yl-4-2-pyridyl-benzamide dihydrochloride
PubChem CID 90488894
IUPAC Name N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-4-pyridin-2-ylbenzamide;dihydrochloride
SMILES C1CN(CCN1CC=CCNC(=O)C2=CC=C(C=C2)C3=CC=CC=N3)C4=C(C(=CC=C4)Cl)Cl.Cl.Cl

Specifications

Quantity 10 mg
Formula Weight 554.34
Percent Purity >99%
Chemical Name or Material PG 01037 dihydrochloride

Safety and Handling

Recommended Storage Desiccate at +4°C
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