Thermo Scientific™ Sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate), No-Weigh™ Format

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker made of NHS-ester and maleimide groups at ends of a cyclohexane-containing, 8-atom spacer arm.

Thermo Scientific™ Pierce Sulfo-SMCC is a very popular, water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 Ås).

• Reactive groups: sulfo-NHS ester and maleimide
• Reactive towards: amino and sulfhydryl groups
• Water-soluble (compare to SMCC), so crosslinking can be done in physiologic solutions
• High purity, crystalline reagent can be used to create high-purity maleimide-activated derivatives
• Cyclohexane bridge confers added stability to the maleimide group making Sulfo-SMCC the ideal crosslinking agent for maleimide activation of proteins. Maleimide groups are stable for 64 hours in 0.1 M sodium phosphate buffer, pH 7 at 4°C.

Chemical Reactivity

Amine-Sulfhydryl

Cleavable

No

Description

Sulfo-SMCC

Molecular Weight (g/mol)

436.37

PEGylated

No

Spacer Arm Length

8.3 Å

Content And Storage

Upon receipt store desiccated at -20°C.

Cell Permeability

No

Shipping Condition

Ambient

Product Line

No-Weigh™

Labeling Method

Chemical Labeling

Crosslinker Type

Heterobifunctional

Reactive Moiety

Maleimide, Sulfo-NHS Ester

Spacer

Short (<10 Å)

Form

Solid

Quantity

10 x 2 mg

Solubility

Water

Format

Standard, Single-use, Premium-grade

Water Soluble

Yes

Product Type

Crosslinker

For Research Use Only. Not for use in diagnostic procedures.