Polymixin B Sulfate, Fisher BioReagents

Interferes with cytoplasmic membrane

• Polymixin B Sulfate is an antibiotic used to prevent bacterial contamination of cell cultures
• Disrupts the permeability of the cytoplasmic membrane  which leads to cell death
• This antibiotic is highly effective against gram-negative bacteria
• Intended for research use only

Chemical Identifiers

CAS

1405-20-5

Molecular Formula

C48H84N16O17S

Molecular Weight (g/mol)

1189.36

MDL Number

MFCD00131991

InChI Key

HNDFYNOVSOOGDU-UHFFFAOYNA-N

PubChem CID

133109994

IUPAC Name

4-amino-N-{1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-3-hydroxypropyl}-2-formamidobutanamide; sulfuric acid

SMILES

OS(O)(=O)=O.CC(C)CC1NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC(=O)C(CCNC(=O)C(CCO)NC(=O)C(CCN)NC(=O)C(CCN)NC1=O)NC(=O)C(CCN)NC(=O)C(CCO)NC(=O)C(CCN)NC=O

Type

Polymixin B Sulfate

Physical Form

Solid

Source

Bacillus polymyxa

Loss on Drying

< 7.0%

Packaging

Amber Glass

Concentration

>6000 U/mg

Quantity

1 g

Merck Index

15, 7693

Formula Weight

1385.61

Percent Purity

>6000 U/mg

Chemical Name or Material

Polymixin B Sulfate

Hazard Statement

WARNING!

Precautionary Statement

Emergency Overview
Harmful if swallowed. Use personal protective equipment. Ensure adequate ventilation. Wash off immediately with plenty of water for at least 15 minutes. Get medical attention immediately if symptoms occur. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Obtain medical attention. Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artifici. Get medical attention immediately if symptoms occur. Do not induce vomiting. Do not induce vomiting. Call a physician or Poison Control Center immediately.

NFPA

Health:2
Flammability:0
Instability:0

SDS

Hazard Statement

WARNING!

Precautionary Statement

Emergency Overview
Harmful if swallowed. Use personal protective equipment. Ensure adequate ventilation. Wash off immediately with plenty of water for at least 15 minutes. Get medical attention immediately if symptoms occur. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Obtain medical attention. Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artifici. Get medical attention immediately if symptoms occur. Do not induce vomiting. Do not induce vomiting. Call a physician or Poison Control Center immediately.

NFPA

Health:2
Flammability:0
Instability:0

SDS