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Probenecid, Tocris Bioscience™

Catalog No. 410750 Shop All R&D Systems Products
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

MRP inhibitor

Probenecid is an inhibitor of multidrug resistance-associated proteins (MRP). Probenicid inhibits OAT3, organic acid transport in the kidney and other organs and exhibits inhibitory activity against pannexin 1 channels (IC50 ∼ 150 μM). Probenecid potently inhibits SARS-CoV-2 replication in NHBE and Vero E6 cells (IC50 = 1.3 nM and 750 nM, respectively) and reduces lung virus titers in vivo. Probenicid also inhibits influenza A virus replication in vitro and in vivo.

Chemical Identifiers

CAS 57-66-9
Molecular Formula C13H19NO4S
Molecular Weight (g/mol) 285.36
MDL Number MFCD00038402
InChI Key DBABZHXKTCFAPX-UHFFFAOYSA-N
Synonym probenecid, 4-dipropylsulfamoyl benzoic acid, probenecid acid, probecid, benecid, benemid, benuryl, probalan, probenemid, probexin
PubChem CID 4911
ChEBI CHEBI:8426
IUPAC Name 4-(dipropylsulfamoyl)benzoic acid
SMILES CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(O)=O

Specifications

Quantity 50 mg
Formula Weight 285.36
Percent Purity >98%
Chemical Name or Material Probenecid

Safety and Handling

Recommended Storage Store at Room Temperature
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