Progesterone, 98%, Thermo Scientific Chemicals

Progesterone, CAS # 57-83-0, is a naturally occurring hormone required for maintenance of the uterine endothelium and suppression of estrogens.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Progesterone is a sex hormone required for suppression of estrogen signaling and is also involved in transcriptional activation

• Progesterone maintains the uterine endothelium and sustains pregnancy through suppression of muscle contractility

Applications

• Progesterone signaling is relevant to the study of breast cancer

Literature References

Kim, O.; Park, E.Y.; Kwon, S.Y.; Shin, S.; Emerson, R.E.; Shin, Y.H.; DeMayo, F.J.; Lydon, J.P.; Coffey, D.M.; Hawkins, S.M.; Quilliam, L.A.; Cheon, D.J.; Fernández, F.M.; Nephew, K.P.; Karpf, A.R.; Widschwendter, M.; Sood, A.K.; Bast, R.C. Jr.; Godwin, A.K.; Miller, K.D.; Cho, C.H.; Kim, J. Targeting progesterone signaling prevents metastatic ovarian cancer. Proc Natl Acad Sci U S A. 2020, 117(50), 31993-32004.

Jain, V.; McDonald, S.D.; Mundle, W.R.; Farine, D. Guideline No. 398: Progesterone for Prevention of Spontaneous Preterm Birth. J Obstet Gynaecol Can. 2020, 42(6), 806-812.

Chemical Identifiers

CAS

57-83-0

Molecular Formula

C₂₁H₃₀O₂

Molecular Weight (g/mol)

314.46

MDL Number

MFCD00003658

InChI Key

RJKFOVLPORLFTN-LEKSSAKUSA-N

Synonym

progesterone, agolutin, luteohormone, pregn-4-ene-3,20-dione, crinone, 4-pregnene-3,20-dione, corpus luteum hormone, progestin, syngesterone, utrogestan

PubChem CID

5994

ChEBI

CHEBI:17026

IUPAC Name

(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

SMILES

CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Melting Point

126°C to 131°C

Color

Brown-Yellow to Yellow

Loss on Drying

0.5% max. (500 mg, 105°C, 2 hrs)

Infrared Spectrum

Authentic

Assay Percent Range

97.5% min. (HPLC)

Packaging

Glass bottle

Quantity

5 g

Merck Index

15, 7889

Specific Rotation Condition

+190° (20°C c=1,ethanol)

Specific Rotation

+ 190

Solubility Information

Solubility in water: insoluble. Other solubilities: soluble in alcohol,acetone,dioxane,conc. h2so4

Formula Weight

314.46

Percent Purity

98%

Physical Form

Crystalline Powder, Crystals or Chunks

Chemical Name or Material

Progesterone

Hazard Category

GHS Signal Word: Warning

Hazard Statement

GHS H Statement:
Suspected of causing cancer.

Precautionary Statement

GHS P Statement:
Use personal protective equipment as required.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

EINECSNumber

200-350-6

SDS

Hazard Category

GHS Signal Word: Warning

Hazard Statement

GHS H Statement:
Suspected of causing cancer.

Precautionary Statement

GHS P Statement:
Use personal protective equipment as required.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

EINECSNumber

200-350-6

SDS

RUO – Research Use Only