Thermo Scientific™ ProPac™ WCX-10 Carboxylate Ion Exchange HPLC Column, 10 μm, 4 mm x 250 mm

Column Format: Analytical Column Set (3 Columns, 3 Lots); Pore Size: Nonporous; Column Phase: Ion Exchange

Use Thermo Scientific™ ProPac™ WCX-10 LC Columns to provide exceptionally high resolution for separations of proteins and their variants. Based on stationary phases composed of 10μm nonporous polymeric beads, ProPac columns resolve isoforms that differ by a single charged residue. A thin, hydrophilic layer grafted to the particle core eliminates unwanted secondary interactions. The cation-exchange surface provides pH-based selectivity control and fast mass transfer for high-efficiency separation and moderate capacity.

Multiple Formats for Greater Flexibility

• ProPac WCX-10 column is a weak cation-exchanger with a carboxylate functional group
• Column sizes range from 2mm I.D., for analytical work, up to 22mm I.D. for semi-prep work

Superior Performance for Protein Analysis

• Ideal for characterization and quality control assessment of MAbs and other proteins
• Well-suited for characterization of related protein variants including deamidation and MAb lysine truncation variants
• Unequaled high-resolution separations
• Unmatched column-to-column and lot-to-lot reproducibility eliminates column variability as a concern in stability and QA/QC testing

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Column Format

Analytical Column Set (3 Columns, 3 Lots)

Diameter (Metric)

4 mm

Flow Rate

1 mL/min

Length (Metric)

250 mm

Max. Pressure

3000 psi (207 bar)

Mobile Phase Compatibility

pH 2 to 12, 80% compatible with acetonitrile and acetone, compatible with nonionic and zwitterionic detergents, incompatible with cationic detergents

Particle Size

10 μm

pH

2 to 12

Pore Size

Nonporous

Temperature

60°C

Stationary Phase

Carboxylate

Product Line

ProPac

Packing Material

Spherical, Nonporous Polymer

Column Type

Ion Exchange

Phase

Ion Exchange

Type

Column Set

Technique

Bio-LC