Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Phenylpropanoids and polyketides
  6. Macrolactams
  7. 40421

PSC 833, Tocris Bioscience™

Catalog No. 40421 Shop All R&D Systems Products
Click to view available options
Quantity:
1 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Inhibitor of P-gp-mediated MDR

P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).

Chemical Identifiers

CAS 121584-18-7
Molecular Formula C63H111N11O12
Molecular Weight (g/mol) 1214.65
MDL Number MFCD00907207
InChI Key YJDYDFNKCBANTM-QCWCSKBGSA-N
Synonym valspodar, amdray, sdz psc 833, sdz-psc-833, 3'-keto-bmt 1-val 2-cyclosporin a, unii-q7zp55kf3x, amdray tn, valspodar usan/inn, q7zp55kf3x, sdz-psc 833
PubChem CID 5281884
ChEBI CHEBI:8985
IUPAC Name (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-1,4,7,10,12,15,19,25,28-nonamethyl-33-[(2R,4E)-2-methylhex-4-enoyl]-6,9,18,24-tetrakis(2-methylpropyl)-3,21,30-tris(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
SMILES C\C=C\C[C@@H](C)C(=O)[C@@H]1N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@@H](NC1=O)C(C)C)C(C)C

Specifications

Quantity 1 mg
Formula Weight 1214.62
Percent Purity >98%
Chemical Name or Material PSC 833

Safety and Handling

Recommended Storage Store at -20°C
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.