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Purmorphamine, Tocris Bioscience™

Catalog No. p-4835957 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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Description

Smo receptor agonist

Purmorphamine is a smoothened (Smo) receptor agonist (EC50 ∼ 1 μM) and activates the Hedgehog pathway. Purmorphamine induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, Purmorphamine can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Purmorphamine induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts, and of spinal motor neurons from pluripotent human stem cells, and protects dopaminergic neurons in a mouse model of Parkinson's disease.

Chemical Identifiers

CAS 483367-10-8
Molecular Formula C31H32N6O2
Molecular Weight (g/mol) 520.637
InChI Key FYBHCRQFSFYWPY-UHFFFAOYSA-N
Synonym purmorphamine, 2-1-naphthoxy-6-4-morpholinoanilino-9-cyclohexylpurine, unii-pb12m2f8ky, shh signaling antagonist vi, pb12m2f8ky, 9-cyclohexyl-n-4-morpholin-4-yl phenyl-2-naphthalen-1-yloxy-9h-purin-6-amine, 9-cyclohexyl-n-4-4-morpholinyl phenyl-2-1-naphthalenyloxy-9h-purin-6-amine, 2-1-napthoxy-6-4-morpholinoanilino-9-cyclohexylpurine, 9-cyclohexyl-n-4-morpholin-4-ylphenyl-2-naphthalen-1-yloxypurin-6-amine
PubChem CID 5284329
ChEBI CHEBI:63053
IUPAC Name 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine
SMILES C1CCC(CC1)N2C=NC3=C2N=C(N=C3NC4=CC=C(C=C4)N5CCOCC5)OC6=CC=CC7=CC=CC=C76

Specifications

Quantity 10 mg
Formula Weight 520.62
Chemical Name or Material Purmorphamine

Safety and Handling

Recommended Storage Store at -20°C
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