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  7. 391850

Pyrimethamine, Tocris Bioscience™

Catalog No. 391850 Shop All R&D Systems Products
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor

Potent inhibitor of multidrug and toxin extrusion (MATE) transporters (Ki values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.

Chemical Identifiers

CAS 58-14-0
Molecular Formula C12H13ClN4
Molecular Weight (g/mol) 248.71
MDL Number MFCD00057350
InChI Key WKSAUQYGYAYLPV-UHFFFAOYSA-N
Synonym pyrimethamine, chloridine, daraprim, chloridin, diaminopyritamin, 5-4-chlorophenyl-6-ethylpyrimidine-2,4-diamine, ethylpyrimidine, pirimetamina, chloridyn, malocide
PubChem CID 4993
ChEBI CHEBI:8673
IUPAC Name 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
SMILES CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1

Specifications

Quantity 50 mg
Formula Weight 248.71
Percent Purity >99%
Chemical Name or Material Pyrimethamine

Safety and Handling

Recommended Storage Store at Room Temperature
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