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Tocris Bioscience™ R 268712

Catalog No. 528850 Shop All R&D Systems Products
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This item is not returnable. View return policy

Potent and selective inhibitor of TGF-βRI

R 268712 is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 = 2.5 nM). Exhibits ∽5000-fold selectivity over p38 MAPK. Suppresses development of renal fibrosis in a unilateral ureteral obstruction model. Also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-Thy1 glomerulonephritis model. Orally bioavailable.

Specifications

Purity

>98%

Quantity

50 mg

Product Type

R 268712

Molecular Weight (g/mol)

363.39

Inhibitors

R 268712

For Research Use Only

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