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R 568 hydrochloride, Tocris Bioscience™

Catalog No. 381550 Shop All R&D Systems Products
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Positive allosteric modulator of human calcium-sensing receptor (CaSR)

Positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR). Exhibits calcimimetic activity. Has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Exerts a suppressive effect on parathyroid (PT) hormone secretion; inhibits PT cell proliferation in rats with renal insufficiency.

Chemical Identifiers

CAS

177172-49-5

Molecular Formula

C18H23Cl2NO

Molecular Weight (g/mol)

340.288

InChI Key

YJXUXANREVNZLH-PFEQFJNWSA-N

Synonym

r 568 hydrochloride, tecalcet hydrochloride, tecalcet hcl, norcalcin, unii-3hp28r98lc, tecalcet hydrochloride usan, r-3-2-chlorophenyl-n-1-3-methoxyphenyl ethyl propan-1-amine hydrochloride, 3-2-chlorophenyl propyl 1r-1-3-methoxyphenyl ethyl amine hydrochloride

PubChem CID

158796

IUPAC Name

3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine;hydrochloride

SMILES

CC(C1=CC(=CC=C1)OC)NCCCC2=CC=CC=C2Cl.Cl

Specifications

Quantity

50 mg

Formula Weight

340.29

Percent Purity

>99%

Chemical Name or Material

R 568 hydrochloride

Recommended Storage

Desiccate at Room Temperature
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