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(R)-(+)-Bay K 8644, Tocris Bioscience™

Catalog No. 154550 Shop All R&D Systems Products
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CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644

(R)-(+)-Bay K 8644 is a L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo. Enantiomer showing opposite effects to the racemate (±)-Bay K 8644 (Cat. No. 1544) and (S)-(-)- enantiomer (Cat. No. 1546). Also TMEM176B inhibitor. Induces IL-1β secretion and caspase-1 activation in bone marrow-derived dendritic cells in vitro and increases survival of tumor-bearing mice, both alone and in combination with immune checkpoint blockers.

Racemate and (S)-(-)-Enantiomer also available.

Chemical Identifiers

CAS

98791-67-4

Molecular Formula

C16H15F3N2O4

Molecular Weight (g/mol)

356.301

InChI Key

ZFLWDHHVRRZMEI-CYBMUJFWSA-N

Synonym

r-+-bay k 8644, bay-k-8644 r-+-, methyl 4r-2,6-dimethyl-5-nitro-4-2-trifluoromethyl phenyl-1,4-dihydropyridine-3-carboxylate, bay-k-8644 r-+, tocris-1546, bidd:pxr0106, r-bayk8644, r-bay k8644, r-bay-k-8644, r + bay k 8644

PubChem CID

6604881

IUPAC Name

methyl (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

SMILES

CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC

Specifications

Quantity

50 mg

Formula Weight

356.3

Percent Purity

>97%

Chemical Name or Material

(R)-(+)-Bay K 8644

Recommended Storage

Store at +4°C
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