MilliporeSigma™ Rabbit anti-phospho-CREB (Ser133), Alexa Fluor 647, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ 06519AF647

Catalog No. 06-519-AF647

Description

Specifically detects phospho-CREB (Ser133) in Human, Mouse, Rat samples, and it is validated for Immunofluorescence

Cyclic AMP-responsive element-binding protein 1 (UniProt P16220; also known as cAMP-responsive element-binding protein 1, CREB-1) is encoded by the CREB1 gene (Gene ID 1385) in human. CREB is a transcription factor that binds the cAMP response elements (CRE) and regulates the transcription of the downstream genes. CREB activity is regulation via phosphorylation by various kinases, including PKA, and Ca²⁺/calmodulin-dependent protein kinases. Genes known to be regulated by CREB include c-fos, BDNF, tyrosine hydroxylase, neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone), as well as the circadian clock genes PER1 and PER2. CREB is critical for memory formation across a wide range of species.

Specifications

• Antigen: phospho-CREB (Ser133)
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
• Gene Symbols: CREB1
• Immunogen: KLH-conjugated synthetic peptide corresponding to the amino acids including and encompassing phosphorylated Ser133 of CREB-A.
• Quantity: 100 μL
• Research Discipline: Epigenetics and Nuclear Function
• Gene ID (Entrez): NP_604391
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

• Applications: Immunofluorescence
• Conjugate: Alexa Fluor 647
• Gene Accession No.: P16220
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Isotype: IgG1

For Research Use Only