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MilliporeSigma™ Rabbit anti-phospho-CREB (Ser133), Alexa Fluor 647, Polyclonal,
Rabbit Polyclonal Antibody
Supplier: MilliporeSigma™ 06519AF647
Description
Specifically detects phospho-CREB (Ser133) in Human, Mouse, Rat samples, and it is validated for Immunofluorescence
Cyclic AMP-responsive element-binding protein 1 (UniProt P16220; also known as cAMP-responsive element-binding protein 1, CREB-1) is encoded by the CREB1 gene (Gene ID 1385) in human. CREB is a transcription factor that binds the cAMP response elements (CRE) and regulates the transcription of the downstream genes. CREB activity is regulation via phosphorylation by various kinases, including PKA, and Ca2+/calmodulin-dependent protein kinases. Genes known to be regulated by CREB include c-fos, BDNF, tyrosine hydroxylase, neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone), as well as the circadian clock genes PER1 and PER2. CREB is critical for memory formation across a wide range of species.Specifications
phospho-CREB (Ser133) | |
Polyclonal | |
Purified rabbit polyclonal antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide. | |
CREB1 | |
KLH-conjugated synthetic peptide corresponding to the amino acids including and encompassing phosphorylated Ser133 of CREB-A. | |
100 μL | |
Epigenetics and Nuclear Function | |
NP_604391 | |
Stable for one year at 2°C to 8°C from date of receipt. |
Immunofluorescence | |
Alexa Fluor 647 | |
P16220 | |
Rabbit | |
Affinity Purified | |
RUO | |
Primary | |
Human, Mouse, Rat | |
IgG1 |
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For Research Use Only