Ribavirin, MP Biomedicals™

Active against many DNA and RNA viruses. Ribavirin, MP Biomedicals is an antiviral compound that is active against RSV, HIV, HCV and other infectious agents. It is a nucleoside antimetabolite drug that interferes with duplication of viral genetic material

Ribavirin is used as an antiviral agent against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. It inhibits purine (GTP pools) biosynthesis and is a precursor to the di- and tri-phosphates that inhibit viral RNA-dependent RNA polymerases. Its metabolite, ribavirin 5'-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence. It is also an analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.

Chemical Identifiers

CAS

36791-04-5

Molecular Formula

C8H12N4O5

Molecular Weight (g/mol)

244.207

InChI Key

IWUCXVSUMQZMFG-AFCXAGJDSA-N

Synonym

ribavirin, tribavirin, virazole, rebetol, ribavirine, copegus, vilona, ribamide, ribamidil, ribasphere

PubChem CID

37542

ChEBI

CHEBI:63580

IUPAC Name

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide

SMILES

C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N

Melting Point

173°C (literature)

Loss on Drying

0.04% (Lit.)

Quantity

250mg

Solubility Information

Soluble in water (20mg/mL, clear, colorless solution).

Formula Weight

244.2g/mol

Physical Form

White Powder

Percent Purity

>99%

Recommended Storage

Store at 4°C.

Recommended Storage

Store at 4°C.