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Ribavirin, Tocris Bioscience™

Catalog No. 450150 Shop All R&D Systems Products
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Serine protease inhibitor; inhibits tryptase

Antiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (Ki ∽ 0.3 μM for the active metabolite, ribavirin triphosphate). Also inosine monophosphate dehydrogenase (IMPDH) inhibitor. Represses colony formation of primary AML-M5 progenitor cells (IC50 ∽ 1 μM); reduces disease severity in acute myeloid leukemia (AML). Inhibits cytopathic effect of SARS-CoV in Vero cells in vitro. Orally available.

Chemical Identifiers

CAS 36791-04-5
Molecular Formula C8H12N4O5
Molecular Weight (g/mol) 244.207
InChI Key IWUCXVSUMQZMFG-AFCXAGJDSA-N
Synonym ribavirin, tribavirin, virazole, rebetol, ribavirine, copegus, vilona, ribamide, ribamidil, ribasphere
PubChem CID 37542
ChEBI CHEBI:63580
IUPAC Name 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
SMILES C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N

Specifications

Quantity 50 mg
Formula Weight 244.2
Percent Purity >99%
Chemical Name or Material Protein-synthesizing GTPase Compounds

Safety and Handling

Recommended Storage Store at +4°C
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