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Ro 08-2750, Tocris Bioscience™

Catalog No. p-4784416 Shop All R&D Systems Products
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Quantity:
1 mg
10 mg
50 mg
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This item is not returnable. View return policy

Description

Inhibits NGF binding to p75NTR and TrkA

Non-peptide inhibitor of NGF that binds the NGF dimer (KD ∽ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells. Suppresses cancer cell proliferation via regulation of Hippo signaling aand YAP phosphorylation.

Chemical Identifiers

CAS 37854-59-4
Molecular Formula C13H10N4O3
Molecular Weight (g/mol) 270.248
InChI Key JDEMVNYMYPJJIM-UHFFFAOYSA-N
Synonym 7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo g pteridine-8-carbaldehyde, 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxobenzo g pteridine-8-carboxaldehyde, 7,10-dimethyl-2,4-dioxo-3h-benzo g pteridine-8-carbaldehyde
PubChem CID 17756791
IUPAC Name 7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carbaldehyde
SMILES CC1=CC2=C(C=C1C=O)N(C3=NC(=O)NC(=O)C3=N2)C

Specifications

Quantity 1 mg
Formula Weight 270.24
Percent Purity >96%
Chemical Name or Material Ro 08-2750

Safety and Handling

Recommended Storage Store at -20°C
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