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Rotenone, Tocris Bioscience™

Catalog No. 361650 Shop All R&D Systems Products
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Inhibits complex I of the mitochondrial electron transport chain

Mitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 μM at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.

Chemical Identifiers

CAS 83-79-4
Molecular Formula C23H22O6
Molecular Weight (g/mol) 394.423
InChI Key JUVIOZPCNVVQFO-HBGVWJBISA-N
Synonym rotenone, dactinol, paraderil, --rotenone, tubatoxin, barbasco, --cis-rotenone, derrin, derris, cube root
PubChem CID 6758
ChEBI CHEBI:28201
SMILES CC(=C)C1CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC

Specifications

Quantity 50 mg
Formula Weight 394.42
Percent Purity >95%
Chemical Name or Material Rotenone

Safety and Handling

Recommended Storage Store at Room Temperature
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