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AdipoGen Ruxolitinib phosphate salt
SDP

Supplier:  AdipoGen AGCR13645M025

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Chemical. CAS 1092939-17-7. Formula C17H18N6 . H3O4P. MW 306.4 . 98.0. Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 IC50=322nM. Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.

Catalog No. 50-256-2254


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