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(S)-Crizotinib, >98%, Tocris Bioscience™

Catalog No. 602550 Shop All R&D Systems Products
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MTH1 inhibitor

Potent MTH1 inhibitor (IC50 = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro. Suppresses tumor growth ∽50% in a colon cancer carcinoma xenograft model.

Chemical Identifiers

CAS

1374356-45-2

Molecular Formula

C21H22Cl2FN5O

Molecular Weight (g/mol)

450.339

InChI Key

KTEIFNKAUNYNJU-LBPRGKRZSA-N

Synonym

s-crizotinib, ent-crizotinib, s-3-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-yl-1h-pyrazol-4-yl pyridin-2-amine, 3-1s-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-ylpyrazol-4-yl pyridin-2-amine, tube712, d03ozd, s-crizotinib hplc, s-3-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-yl-1h-pyrazol-4-yl pyridin-2-am ine, 3-1s-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-4-piperidinyl-1h-pyrazol-4-yl-2-pyridinamine, 3-1s-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-yl-1h-pyrazol-4-yl pyridin-2-amine

PubChem CID

56671814

ChEBI

CHEBI:77555

IUPAC Name

3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

SMILES

CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

Specifications

Linear Formula

C21H22Cl2FN5O

Quantity

50mg

Solubility Information

Soluble to 50mM in DMSO and to 20mM in 1eq. HCl with gentle warming

Formula Weight

450.34

Chemical Name or Material

3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

Grade

>98%

Recommended Storage

Store at RT
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