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(S)-Duloxetine hydrochloride, Tocris Bioscience™

Catalog No. 479850 Shop All R&D Systems Products
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Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake

High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

Chemical Identifiers

CAS

136434-34-9

Molecular Formula

C18H20ClNOS

Molecular Weight (g/mol)

333.87

MDL Number

MFCD06407958,MFCD06801358

InChI Key

BFFSMCNJSOPUAY-LMOVPXPDSA-N

Synonym

(+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride

PubChem CID

87834970

IUPAC Name

hydrogen methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine chloride

SMILES

[H+].[Cl-].CNCC[C@H](OC1=C2C=CC=CC2=CC=C1)C1=CC=CS1

Specifications

Quantity

50 mg

Formula Weight

333.88

Percent Purity

>99%

Chemical Name or Material

(S)-Duloxetine hydrochloride

Recommended Storage

Store at Room Temperature
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