Thermo Scientific Chemicals SB 225002

Catalog Number	Mfr. No.	Quantity
AAJ65387MA	Thermo Scientific Chemicals J65387MA	10 mg

Description

SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chemical Identifiers

• CAS: 182498-32-4
• Molecular Formula: C₁₃H₁₀BrN₃O₄, C13H10BrN3O4
• Synonym: 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea

Specifications

• Description: Yellow
• For Use With (Application): A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2
• Molecular Formula: C₁₃H₁₀BrN₃O₄, C13H10BrN3O4
• Synonym: 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
• Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
• Form: Solid
• SMILES: OC1=C(NC(=O)NC2=CC=CC=C2Br)C=CC(=C1)[N+]([O-])=O
• Molecular Weight (g/mol): 352.14

• Content And Storage: -30°C to -10°C
• CAS: 182498-32-4
• Formula Weight: 352.10g/mol
• Sensitivity: Moisture Sensitive
• Product Type: Signal Transduction Reagent
• InChI Key: MQBZVUNNWUIPMK-UHFFFAOYSA-N
• IUPAC Name: 3-(2-bromophenyl)-1-(2-hydroxy-4-nitrophenyl)urea

Safety and Handling

Recommended Storage : Store at -20°C; Store under Nitrogen

RUO – Research Use Only