Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Azoles
  7. Oxadiazoles
  8. SB 674042, Tocris Bioscience™

SB 674042, Tocris Bioscience™

Catalog No. p-4835961 Shop All R&D Systems Products
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective non-peptide OX1 antagonist

Potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM). Exhibits 100-fold selectivity for OX1 over OX2 receptors. Has no effect at serotonergic, dopaminergic, adrenergic or purinergic receptors. Inhibits orexin 1-induced Ca2+ mobilization in CHO-DG44 cells stably transfected with the OX1 receptor.

Chemical Identifiers

CAS 483313-22-0
Molecular Formula C24H21FN4O2S
Molecular Weight (g/mol) 448.516
InChI Key HYBZWVLPALMACV-KRWDZBQOSA-N
Synonym 5-2-fluorophenyl-2-methyl-1,3-thiazol-4-yl-2s-2-5-phenyl-1,3,4-oxadiazol-2-yl methyl pyrrolidin-1-yl methanone, 2-2s-1-5-2-fluorophenyl-2-methyl-1,3-thiazole-4-carbonyl pyrrolidin-2-yl methyl-5-phenyl-1,3,4-oxadiazole, 5-2-fluorophenyl-2-methyl-1,3-thiazol-4-yl 2s-2-5-phenyl-1,3,4-oxadiazol-2-yl methyl pyrrolidin-1-yl methanone, 5-2-fluorophenyl-2-methyl-4-thiazolyl 2 s-2-5-phenyl-1,3,4-oxadiazol-2-yl methyl-1-pyrrolidinyl methanone, 4ot
PubChem CID 10204153
IUPAC Name [5-(2-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]-[(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-1-yl]methanone
SMILES CC1=NC(=C(S1)C2=CC=CC=C2F)C(=O)N3CCCC3CC4=NN=C(O4)C5=CC=CC=C5

Specifications

Quantity 10 mg
Formula Weight 448.51
Chemical Name or Material SB 674042

Safety and Handling

Recommended Storage Store at +4°C
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.