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  7. SCIO 469 hydrochloride, Tocris Bioscience™

SCIO 469 hydrochloride, Tocris Bioscience™

Catalog No. p-4816849 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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MTO (Made-To-Order) item. This item is subject to the following cancellation policy: This item may be cancelled within 10 days of order placement otherwise is not returnable for credit
This item is not returnable. View return policy
MTO (Made-To-Order) item. This item is subject to the following cancellation policy: This item may be cancelled within 10 days of order placement otherwise is not returnable for credit

Description

Selective p38 MAPK inhibitor

SCIO 469 hydrochloride is a selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Displays approximately 10-fold selectivity for p38α over p38β and 2000-fold selectivity for p38α over 20 other kinases. Reduces p38α phosphorylation in multiple myeloma cells in vitro and in vivo; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib -induced cytotoxicity against multiple myeloma cells.

Chemical Identifiers

CAS 309913-83-5
Molecular Formula C27H30ClFN4O3
Molecular Weight (g/mol) 513.01
InChI Key ZMELOYOKMZBMRB-DLBZAZTESA-N
Synonym talmapimod, scio-469, scios 469, scio 469, unii-b1e00kq6nt, b1e00kq6nt, scio 469 hydrochloride, 2-6-chloro-5-2r,5s-4-4-fluorobenzyl-2,5-dimethylpiperazin-1-yl carbonyl-1-methyl-1h-indol-3-yl-n,n-dimethyl-2-oxoacetamide, talmapimod usan, talmapimod usan:inn
PubChem CID 9871074
IUPAC Name 2-[6-chloro-5-[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine-1-carbonyl]-1-methylindol-3-yl]-N,N-dimethyl-2-oxoacetamide
SMILES CC1CN(C(CN1C(=O)C2=C(C=C3C(=C2)C(=CN3C)C(=O)C(=O)N(C)C)Cl)C)CC4=CC=C(C=C4)F

Specifications

Quantity 10 mg
Formula Weight 549.46
Percent Purity >98%
Chemical Name or Material SCIO 469 hydrochloride

Safety and Handling

Recommended Storage Desiccate at +4°C.
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