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SD 208, Tocris Bioscience™

Catalog No. 326950 Shop All R&D Systems Products
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Potent ATP-competitive TGF-βRI inhibitor

Potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50 = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity. Also promotes an antiglioma immune response. Ameliorates germinal matrix hemorrhage-induced neurological deficits in neonatal rats.

Chemical Identifiers

CAS

627536-09-8

Molecular Formula

C17H10ClFN6

Molecular Weight (g/mol)

352.76

MDL Number

MFCD11519969

InChI Key

BERLXWPRSBJFHO-UHFFFAOYSA-N

Synonym

alk5 inhibitor v, 2-5-chloro-2-fluorophenyl-n-pyridin-4-yl pteridin-4-amine, 2-5-chloro-2-fluorophenyl pteridin-4-yl pyridin-4-yl-amine, 2-5-chloro-2-fluorophenyl-n-pyridin-4-ylpteridin-4-amine, 2-5-chloro-2-fluorophenyl pteridin-4-yl pyridin-4-yl amine, transforming growth factor-beta type i receptor kinase inhibitor v, d0v8ac, tgf-, a ri kinase inhibitor v, tgf-ri kinase inhibitor v, 2-5-chloro-2-fluorophenyl-4-4-pyridyl amino pteridine

PubChem CID

10316032

IUPAC Name

2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine

SMILES

FC1=C(C=C(Cl)C=C1)C1=NC(NC2=CC=NC=C2)=C2N=CC=NC2=N1

Specifications

Quantity

50 mg

Formula Weight

352.75

Percent Purity

>98%

Chemical Name or Material

SD 208

Recommended Storage

Store at Room Temperature
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