Securin Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Invitrogen 341500

Catalog No. 34-150-0

Description

Pituitary tumor-transforming gene 1 (PTTG-1) is an oncogene expressed in normal tissues containing proliferating cells and in tumors. PTTG is downstream of the MAP kinase signaling cascade and is phosphorylated at Ser162 by MAPK in vitro. Phosphorylation plays an essential role in PTTG′s transactivation function. The PTTG protein contains a DNA-binding domain, and it activates transcription of the c-Myc oncogene by binding to the promoter to form a complex. Studies have demonstrated that expression of human PTTG correlates with cell proliferation in a cell cycledependent manner, and the association of human PTTG with Ku, the regulatory subunit of DNA-dependent protein kinase, is disrupted when a DNA double-strand breaks occurs.

Specifications

• Antigen: Securin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pttg1
• Gene Alias: AW555095; C87862; EAP1; Esp1-associated protein; ESP1-associated protein 1; HPTTG; MGC126883; MGC138276; Pituitary tumor transforming; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1; pituitary tumor-transforming gene 1 protein; PTTG; PTTG1; Pttg3; Securin; tumor-transforming protein 1; TUTR1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9232
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: O95997
• Gene Symbols: Pttg1
• Immunogen: Synthetic peptide derived from the transactivation domain within the N-terminus of the human PTTG-1 protein
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG