Simvastatin, Tocris Bioscience™

Description

HMG-CoA reductase inhibitor

HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Deuterated analog also available.

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Specifications

Chemical Identifiers

• CAS: 79902-63-9
• Molecular Formula: C25H38O5
• Molecular Weight (g/mol): 418.574
• InChI Key: RYMZZMVNJRMUDD-HGQWONQESA-N
• Synonym: simvastatin, zocor, synvinolin, sinvacor, denan, lipex, simvastatine, sivastin, lodales, simvastatina
• PubChem CID: 54454
• ChEBI: CHEBI:9150
• IUPAC Name: [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
• SMILES: CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C

• Quantity: 50 mg
• Formula Weight: 418.57
• Percent Purity: >98%
• Chemical Name or Material: Simvastatin

Safety and Handling

Recommended Storage

Desiccate at -20°C