Sirt1 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A300688AT

Catalog No. 50-155-8221

Description

The recommended shelf life for this product is 1 year from date of receipt.

SIRT1, the human homolog of the S. cerevisiae Sir2 protein, functions as an NAD-dependent deacetylase of a number of nonhistone substrates including p53. In response to DNA damage, SIRT1 binds and deacetylates the p53 protein at c-terminal Lys382 residue and attenuate p53-mediated functions. When overexpressed in mouse embryo fibroblasts, SIRT1 antagonizes PML-induced acetylation of p53 and rescues PML-mediated premature cellular senescence. In mammalian cells, SIRT1 appears to control the cellular response to stress by regulating the FOXO family of forkhead transcription factors.

Specifications

• Antigen: Sirt1
• Classification: Polyclonal
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Accession No.: Q96EB6
• Gene Symbols: SIRT1
• Immunogen: Between 700 and C-term
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: SIRT1
• Gene Alias: NAD-dependent deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; SIR2-like protein 1; SIR2alpha; hSIR2; hSIRT1; sir2-like 1; sirtuin type 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23411
• Content And Storage: 4° C
• Form: Liquid