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TARGETMOL CHEMICALS INC SKF-96365 HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SKF-96365 hydrochloride (SKF96365) a SOCE inhibitor exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically SKF-96365 hydrochloride treatment inhibited the calcium/calmodulin-dependent protein kinase II(gamma) (CaMKII(gamma))/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKII(gamma) or AKT abolished the effects of SKF-96365 on Y cells suggesting a critical role of the CaMKII(gamma)/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 hydrochloride inhibited hERG current in a concentration-dependent manner. purity: 99%
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