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Tocris™ SM 16

Catalog No. 624510 Shop All R&D Systems Products
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10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent TGF-β receptor type 1 (TGF-βRI) inhibitor

SM 16 is a potent TGF-β receptor type 1 (TGF-βRI) inhibitor (IC50 = 64 nM in luciferase assay). Selective for TGF-βRI over other ALK family members. Decreases Smad phosphorylation and inhibits tumor growth in a mouse xenograft model. Attenuates increased TGF-β signaling in retinal vessels of diabetic rats. Also prevents intimal thickening and vascular remodeling in rat carotid balloon injury model. Orally bioavailable.

Specifications

Chemical Name or Material 4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide
CAS 614749-78-9
Quantity 10 mg
Molecular Formula C25H26N4O3
Formula Weight 430.5
Product Type Inhibitor
Purity 98%
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