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SNS 032, Tocris Bioscience™

Catalog No. p-4817039 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9

Cyclin dependent kinase (cdk) inhibitor (reported IC50 values are 0.004 - 0.048, 0.0045 - 0.05, 0.062 - 0.29, 0.2-0.48, 0.4 and 0.45 μM for cdk9, cdk2, cdk7, cdk1, cdk5 and cdk4, respectively). Displays no activity against 190 additional kinases (IC50 >1 μM). Arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.

Chemical Identifiers

CAS 345627-80-7
Molecular Formula C17H24N4O2S2
Molecular Weight (g/mol) 380.525
InChI Key OUSFTKFNBAZUKL-UHFFFAOYSA-N
Synonym n-5-5-tert-butyl oxazol-2-yl methyl thio thiazol-2-yl piperidine-4-carboxamide, n-5-5-tert-butyl-1,3-oxazol-2-yl methylsulfanyl-1,3-thiazol-2-yl piperidine-4-carboxamide, n-5-5-tert-butyl-1,3-oxazol-2-yl methyl sulfanyl-1,3-thiazol-2-yl piperidine-4-carboxamide, n-5-5-1,1-dimethylethyl-2-oxazolyl methyl thio-2-thiazolyl-4-piperidinecarboxamide, 4-piperidinecarboxamide, n-5-5-1,1-dimethylethyl-2-oxazolyl methyl thio-2-thiazolyl, kinome_3820, pubchem16670, tube004
PubChem CID 3025986
IUPAC Name N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
SMILES CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3

Specifications

Quantity 10 mg
Formula Weight 380.53
Percent Purity >99%
Chemical Name or Material SNS 032

Safety and Handling

Recommended Storage Store at -20°C
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