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SP 600125, Tocris Bioscience™

Catalog No. p-4785598 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective JNK inhibitor

SP 600125 is a selective JNK inhibitor. Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes. Active in vivo. Exhibits reduced selectivity over other protein kinases under certain conditions. SP 600125 protects renal tubular epithelial cells from ischemia/reperfusion-induced apoptosis. Promotes chondrogenesis of bone mesenchymal stem cells by inhibition of TNF-α-induced inflammation. Adipogenesis from MSCs is also promoted by SP 600125. Essential component of medium for maintaining stem cells in naive pluripotent state.

Chemical Identifiers

CAS 129-56-6
Molecular Formula C14H8N2O
Molecular Weight (g/mol) 220.231
InChI Key ACPOUJIDANTYHO-UHFFFAOYSA-N
Synonym 1,9-pyrazoloanthrone, pyrazolanthrone, dibenzo cd,g indazol-6 2h-one, pyrazoleanthrone, anthra 1,9-cd pyrazol-6 2h-one, anthra-1,9-pyrazol-6-none, 2h-dibenzo cd,g indazol-6-one, jnk inhibitor ii, sapk inhibitor ii
PubChem CID 8515
SMILES C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O

Specifications

Quantity 10 mg
Formula Weight 220.23
Percent Purity >98%
Chemical Name or Material SP 600125

Safety and Handling

Recommended Storage Desiccate at -20°C
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