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  7. SR 12813, Tocris Bioscience™

SR 12813, Tocris Bioscience™

Catalog No. p-4784584 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Pregnane X receptor agonist

SR 12813 is a pregnane X receptor (PXR) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μM concentrations. Displays hypocholesterolemic activity via enhanced degradation of HMG-CoA reductase.

Chemical Identifiers

CAS 126411-39-0
Molecular Formula C24H42O7P2
Molecular Weight (g/mol) 504.541
InChI Key YQLJDECYQDRSBI-UHFFFAOYSA-N
Synonym 4-2,2-bis diethoxyphosphoryl ethenyl-2,6-ditert-butylphenol, tetraethyl 2-3,5-di-tert-butyl-4-hydroxyphenyl ethenyl-1,1-bisphosphonate, 3,5-bis 1,1-dimethylethyl-4-hydroxyphenyl ethenylidene bis-phosphonic acid tetraethyl ester, 2-3,5-di-tert-butyl-4-hydroxy-phenyl-1-diethoxy-phosphoryl-vinyl-phosphonic acid diethlyl ester, srl, 1ilh, d0c7rv, bidd:pxr0009, sr, solid, tetraethyl 2-3,5-di-tert-butyl-4-hydroxyphenyl ethene-1,1-diyl bis phosphonate
PubChem CID 446313
ChEBI CHEBI:77317
IUPAC Name 4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol
SMILES CCOP(=O)(C(=CC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C)P(=O)(OCC)OCC)OCC

Specifications

Quantity 10 mg
Formula Weight 504.53
Percent Purity >99%
Chemical Name or Material SR 12813

Safety and Handling

Recommended Storage Store at +4°C
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