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Enzo Life Sciences Streptozotocin, (1g), CAS Number: 18883-66-4
O-GlcNAcase inhibitor. Widely used diabetes inducer in rodents. Inhibition of β-cell O-GlcNAcase by streptozotocin is the mechanism that accounts for its diabetogenic toxicity. N-nitroso-containing antibiotic, acting as a nitric oxide (NO) donor and vasorelaxant. Relaxes phenylephrine-contracted aortic rings at 10µM. Potent methylating agent for DNA. Alternative Name: Streptozocin, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose, STZ. Formula: C8H15N3O7. MW: 265.2. CAS Number: 18883-66-4. MI: 14: 8832. Purity: ≥97% (Assay). Appearance: White to pale yellow crystalline solid. Solubility: Soluble in water (nH2O at 102.8mg/ml) or 100% ethanol (200 proof at 0.92mg/ml). Use/Stability: Because solutions of the compound spontaneously give off NO gas at room temperature, we recommend that solutions be made immediately before use. Long Term Storage: -20°C
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