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  8. 33001

SU 5402, Tocris Bioscience™

Catalog No. 33001 Shop All R&D Systems Products
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Quantity:
1 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent FGFR and VEGFR inhibitor

Potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo. Also attenuates integrin β4-induced differentiation of neural stem cells.

Chemical Identifiers

CAS 215543-92-3
Molecular Formula C17H16N2O3
Molecular Weight (g/mol) 296.326
InChI Key JNDVEAXZWJIOKB-JYRVWZFOSA-N
Synonym 3-3-2-carboxyethyl-4-methylpyrrol-2-methylidenyl-2-indolinone, z-3-4-methyl-2-2-oxoindolin-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, chembl89363, 3-3-2-carboxyethyl-4-methylpyrrol-2-yl methylene-2-indolinone, 3-4-methyl-2-3z-2-oxo-1h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, 3-4-methyl-2-2-oxo-1,2-dihydro-3h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, pubchem22440, kdr kinase inhibitor, 5, d0a4xj
PubChem CID 5289418
IUPAC Name 3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
SMILES CC1=CNC(=C1CCC(=O)O)C=C2C3=CC=CC=C3NC2=O

Specifications

Quantity 1 mg
Formula Weight 296.32
Percent Purity >95%
Chemical Name or Material SU 5402

Safety and Handling

Recommended Storage Store at -20°C
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