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Pfanstiehl Inc SUCCINIC ACID, HIGH PURITY, LOW ENTOTOXIN, LOW METALS, NF, EP, BP, JPE.CHP, 100G
A dicarboxylic acid with the chemical formula C₄H₆O₄. It naturally occurs in various plants and animals and is an important intermediate in the citric acid cycle (Krebs cycle), which is a key metabolic pathway that generates energy in cells.In Biologic formulations, Succinic acid’s role is to ensure the stability, efficacy, and safety of the biologic product throughout its shelf life and during administration. Succinic acid can act as a buffering agent, maintaining the pH of the formulation within a narrow range. Proteins are sensitive to pH changes, and their stability and activity can be significantly affected if the pH deviates from their optimal range. By buffering the solution, succinic acid helps prevent denaturation or aggregation of proteins caused by pH fluctuations.Succinic acid and its salts can contribute to the ionic strength of the solution. This can reduce the likelihood of protein-protein interactions that lead to aggregation.
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