Thermo Scientific™ Sulfo-NHS (N-hydroxysulfosuccinimide), No-Weigh™ Format

Prepare amine-reactive sulfo-NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysulfosuccinimide, CAS 106627-54-7.

Thermo Scientific™ Pierce Sulfo-NHS is pure N-hydroxysulfosuccinimide, the essential compound needed to prepare water-soluble, amine-reactive NHS-ester crosslinkers or to enhance conjugation efficiencies when using the carbodiimide EDC.

Highlights:

• Forms an acyl amino ester with carboxyl groups when used with the EDC
• Sulfo-NHS-activated molecule reacts efficiently with primary amines, resulting in stable amide bond
• Allows for two-step EDC reactions between carboxyl- and amine-containing molecules
• Sulfo-NHS-activated molecule can be stabilized by drying, allowing manufacture of amine-reactive probes and surfaces
• Reactive groups: Sulfo-NHS
• Reactive toward: amino groups (upon activation of carboxylates)

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Chemical Reactivity

Amine-Carboxyl

Cleavable

No

Description

Sulfo-NHS

Molecular Weight (g/mol)

217.13

PEGylated

No

Content And Storage

Upon receipt store at 4°C.

Cell Permeability

No

Shipping Condition

Ambient

Product Line

Pierce™

Labeling Method

Chemical Labeling

Crosslinker Type

Heterobifunctional

Reactive Moiety

Carbodiimide

Spacer

Short (<10 Å)

Form

Powder

Quantity

500 mg

Solubility

Water

Format

Standard, Single-use, Premium-grade

Water Soluble

Yes

Product Type

Crosslinker

For Research Use Only. Not for use in diagnostic procedures.