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AdipoGen Tamoxifen citrate salt
Supplier: AdipoGen CDXT0201G001
Chemical. CAS 54965-24-1. Formula C26H29NO . C6H8O7. MW 563.64. Synthetic. Selective estrogen receptor modulator SERM used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the cardiovasculature system. This prodrug is metabolized by cytochrome P450 CYP450 enzymes to the active metabolites N-desmethyl-TMX, 4-hydroxy-N-desmethyl-TMX endoxifen and 4-hydroxy-TMX afimoxifene. N,N-Didesmethyl-4-hydroxytamoxifen norendoxifen, another active metabolite has been found to act as a potent competitive aromatase inhibitor and may also be involved in its antiestrogenic activity. Binds microsomal antiestrogen binding sites, altering cholesterol esterification at therapeutic doses and impacting breast cancer cell differentiation, apoptosis, and autophagy. Protein kinase C PKC inhibitor and anti-angiogenetic factor.
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